Article
The 2G allele of promoter region of matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.
BMC cancer - 5 Oct 2007
Nishizawa Rishiho, Nagata Masaki, Noman Arhab A, Kitamura Nobutaka, Fujita Hajime, Hoshina Hideyuki, Kubota Takehiko, Itagaki Manami, Shingaki Susumu, Ohnishi Makoto, Kurita Hiroshi, Katsura Kouji, Saito Chikara, Yoshie Hiromasa, Takagi Ritsuo
Abstract excerpt
BACKGROUND: Matrix metalloproteinase (MMP) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. This study examines the association of single nucleotide polymorphisms in promoter regions of MMP-1 and MMP-3 with susceptibility to oral squamous cell carcinoma (OSCC). METHODS: We compared 170 Japanese OSCC cases and 164 healthy controls for...
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