Article
The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event.
The Journal of rheumatology - 1 Dec 2007
Sebastian Jodi K, Voetsch Barbara, Stone John H, Romay-Penabad Zurina, Lo Grace H, Allen Nancy B, Davis John C, Hoffman Gary S, McCune W Joseph, St Clair E William, Specks Ulrich, Spiera Robert, Loscalzo Joseph, Pierangeli Silvia, Merkel Peter A
Abstract excerpt
OBJECTIVE: Venous thrombotic events (VTE), including both deep venous thrombosis and pulmonary emboli, are now recognized as an important complication of Wegener's granulomatosis (WG), but the mechanism(s) of this occurrence is unclear. The frequency of anticardiolipin antibodies (aCL), anti-beta2-glycoprotein antibodies (anti-beta2-GP), and several genetic hypercoagulable factors were examined in a large cohort...
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