Amyotrophic lateral sclerosis with primary progressive aphasia: a case report and literature review.

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Article

Amyotrophic lateral sclerosis with primary progressive aphasia: a case report and literature review.

Neuro endocrinology letters - 29 Dec 2022

Zhang Anni, Xu Hongbei, Huang Jing, Guo Shipeng, Tian Tian, Lei Xiaoyang, He Dian

Abstract excerpt

The association between amyotrophic lateral sclerosis (ALS) and primary progressive aphasia (PPA) is rarely seen in patients. A case of ALS-PPA with a possible reticulon 2 (RTN2) mutation was reported in this study. Moreover, we systematically reviewed the previous reports of 28 ALS cases with progressive non-fluent aphasia (PNFA) and semantic dementia (SD) to identified the unique pathologic features and strong...

Topics

Male
Female
Humans
Amyotrophic Lateral Sclerosis
C9orf72 Protein
Frontotemporal Dementia
Mutation
Aphasia, Primary Progressive

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Open in PubMed

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PMID: 36586129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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