Article
Disordered meiotic regulation of oocytes by duration of diabetes mellitus in BBdp rat.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Jul 2007
Kim KilSoo, Kim Chung Hoon, Moley Kelle H, Cheon Yong-Pil
Abstract excerpt
Diabetes mellitus (DM) disturbs normal functions from the level of cells to the level of organs. In this study, the authors explore the detrimental effects of type 1 diabetes on meiotic regulation depending on the duration of DM. In non-diabetes-prone BioBreeding (BBdr) control rats, most of the large follicles had germinal vesicle (GV)-intact oocytes. Conversely, a decrease of intact GV that was dependent on the...
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