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Article

Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2007

Tordjman Karen M, Semenkovich Clay F, Coleman Trey, Yudovich Rachel, Bak Stella, Osher Etty, Vechoropoulos Michal, Stern Naftali

Abstract excerpt

Peroxisome proliferator-activated receptor-alpha is widely distributed in the vasculature where it is believed to exert pleiotropic antiatherogenic effects. Its role in the regulation of blood pressure is still unresolved; however, some evidence suggests that it may affect the renin-angiotensin s...

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Identifiers

PMID: 17909121
DOI: 10.1161/HYPERTENSIONAHA.107.094268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17909121-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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