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Article

Definition of Functionally Important Mechanistic Differences among Selective Estrogen Receptor Down-regulators

1 Oct 2007

Abstract excerpt

One subclass of antiestrogens, the selective estrogen receptor down-regulators (SERDs), have received considerable attention of late as they competitively inhibit estrogen binding and induce a rapid, proteasome-dependent degradation of the receptor. Contained within this class of molecules is the steroidal antiestrogen ICI182,780 (faslodex), recently approved for the treatment of metastatic cancer, and...

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PMID: 17909066
DOI: 10.1158/0008-5472.can-07-1590

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