Article
A second gene for otosclerosis, OTSC2, maps to chromosome 7q34-36.
American journal of human genetics - 1 Feb 2001
Van Den Bogaert K, Govaerts P J, Schatteman I, Brown M R, Caethoven G, Offeciers F E, Somers T, Declau F, Coucke P, Van de Heyning P, Smith R J, Van Camp G
Abstract excerpt
Otosclerosis due to abnormal bone homeostasis of the otic capsule is a frequent cause of hearing loss in adults. Usually, the hearing loss is conductive, resulting from fixation of the stapedial footplate, which prevents normal ossicular vibration in response to sound. An additional type of sensorineural hearing loss may be caused by otosclerotic damage to the cochlea. The etiology of the disease is unknown, and...
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