Article
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.
Nature genetics - 1 Nov 2007
Salmon Hillbertz Nicolette H C, Isaksson Magnus, Karlsson Elinor K, Hellmén Eva, Pielberg Gerli Rosengren, Savolainen Peter, Wade Claire M, von Euler Henrik, Gustafson Ulla, Hedhammar Ake, Nilsson Mats, Lindblad-Toh Kerstin, Andersson Leif, Andersson Göran
Abstract excerpt
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more...
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