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Article

Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells

26 Sept 2007

Abstract excerpt

Bone morphogenetic proteins (BMP) are multifunctional cytokines that belong to the TGF-beta superfamily. BMP have been shown to regulate haematopoietic stem cells, B lymphopoiesis and early thymocyte differentiation. In the present study we explored the role of BMP-6 in Jurkat TAg cells. BMP-6 rapidly induced phosphorylation of Smad1/5/8, p38 and ERK1/2, followed by a potent up-regulation of ID1, ID2 and ID3. ID1...

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PMID: 17899540
DOI: 10.1002/eji.200636759

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