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Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

1 Jan 2013

Abstract excerpt

Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug resistance proteins, reduced cellular uptake of the drug, enhanced DNA repair, intracellular drug inactivation, and evasion of apoptosis. Pre-clinical models have demonstrated that many...

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PMID: 23720710
DOI: 10.3389/fonc.2013.00120

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