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Article

Endogenous expression of B7-H4 improves long-term murine islet allograft survival.

Transplantation - 15 Jan 2013

Wang Xiaojie, Hao Jianqiang, Metzger Daniel L, Mui Alice, Lee I-Fang, Akhoundsadegh Noushin, Ao Ziliang, Chen Lieping, Ou Dawei, Verchere C Bruce, Warnock Garth L

Abstract excerpt

BACKGROUND: Allograft rejection is one of the main obstacles for islet transplantation. B7-H4 plays a key role in maintaining T-cell homeostasis by reducing T-cell proliferation and cytokine production. In this study, we investigated whether the endogenous expression of B7-H4 in β cells from B7-H4 transgenic mice enhances islet allograft survival. METHODS: B7-H4 transgenic C57BL/6 (B6) mice (RIP.B7-H4) were...

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Identifiers

PMID: 23192157
DOI: 10.1097/TP.0b013e318277229d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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