Article
The dolabellane diterpene Dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcriptase enzyme.
Antiviral research - 1 Jan 2008
Cirne-Santos Claudio Cesar, Souza Thiago Moreno L, Teixeira Valéria L, Fontes Carlos Frederico L, Rebello Moacyr A, Castello-Branco Luiz Roberto R, Abreu Celina M, Tanuri Amílcar, Frugulhetti Izabel C P P, Bou-Habib Dumith Chequer
Abstract excerpt
We recently described that a dollabelane diterpene isolated from the marine algae Dictyota pfaffii (Dolabelladienetriol) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and HIV-1 replication in primary cells. Based on these findings, we investigated additional antiretroviral properties of Dolabelladienetriol. Here, we describe that Dolabelladienetriol blocked the...
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