Article
Inactivation of human immunodeficiency virus type 1 reverse transcriptase by oltipraz: evidence for the formation of a stable adduct.
Archives of biochemistry and biophysics - 1 Dec 1995
Chavan S J, Bornmann W G, Flexner C, Prochaska H J
Abstract excerpt
Oltipraz (5-pyrazinyl-4-methyl-1,2-dithiole-3-thione), which is undergoing clinical evaluation as an anticarcinogen, also inhibits HIV-1 replication (IC50 approximately equal to 10 microM). The inactivation of RT appears to be a relevant antiviral mechanism since oltipraz blocks viral replication...
Topics
- Antiviral Agents
- Binding Sites
- Chromatography, Affinity
- DNA Polymerase I
- Enzyme Stability
- Escherichia coli
- HIV Reverse Transcriptase
- HIV-1
- Kinetics
- Magnesium
- Mutation
- Pyrazines
- RNA-Directed DNA Polymerase
- Recombinant Proteins
- Reverse Transcriptase Inhibitors
- Thiones
- Thiophenes