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Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase: from the Biology of Reverse Transcription to Molecular Design

1 Sept 2003

Abstract excerpt

Replication of human immunodeficiency virus 1 (HIV-1) uses a viral reverse transcriptase (RT) to convert its positive-strand RNA into double stranded DNA, which is then integrated into host genome. Reverse transcription is a complex event involving p66 and p51 RT subunits but also several viral proteins including Nef, Tat, Vif, IN, NCp7 and p55gag. Viral RNA itself forms a primer/template complex by association...

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PMID: 14529523
DOI: 10.2174/1568026033451754

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