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Article

The key role of mitochondria in Alzheimer's disease

14 Jul 2006

Abstract excerpt

Mitochondria are uniquely poised to play a pivotal role in neuronal cell survival or death because they are regulators of both energy metabolism and apoptotic pathways. This review is mainly focused in the discussion of evidence suggesting a clear association between amyloid-beta toxicity, mitochondrial dysfunction, oxidative stress and neuronal damage/death in Alzheimer's disease pathophysiology. The knowledge...

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PMID: 16873957
DOI: 10.3233/jad-2006-9202

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