Article
Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity.
Journal of molecular medicine (Berlin, Germany) - 1 Feb 2008
Cecchi Cristina, Pensalfini Anna, Stefani Massimo, Baglioni Serena, Fiorillo Claudia, Cappadona Silvia, Caporale Roberto, Nosi Daniele, Ruggiero Marco, Liguri Gianfranco
Abstract excerpt
A key role of mitotic activation in neuronal cell death in early stages of Alzheimer's disease (AD) has been suggested. Apparently, terminally differentiated neurons are precluded from mitotic division, yet some phenotypic markers of cell cycling are present in AD-vulnerable brain areas. In this paper, we investigated whether dividing human neuroblastoma cells are preferentially vulnerable to amyloid aggregate...
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