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Article

The involvement of cell cycle events in the pathogenesis of Alzheimer's disease

1 Jan 2010

Abstract excerpt

Most neurons undergo their last cell division within the first 1 to 2% of the lifespan of an organism. This has been interpreted to mean that adult neurons are permanently postmitotic, but Alzheimer's disease (AD) is an example of a late-onset neurodegenerative disease that challenges this concept. In AD, neurons in populations at risk for death reactivate their cell cycle and replicate their genome - but rather...

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PMID: 20497605
DOI: 10.1186/alzrt37

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