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Article

Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jan 2008

Stein Ulrike, Walther Wolfgang, Stege Alexandra, Kaszubiak Alexander, Fichtner Iduna, Lage Hermann

Abstract excerpt

Triggering the RNA interference (RNAi) pathway by inducing the expression of short hairpin RNA (shRNA) molecules has become a promising tool for efficient silencing of a given gene in gene therapy applications. In this study, shRNA encoding DNA was utilized to reverse the classical MDR1/P-glycopr...

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Source

Identifiers

PMID: 17878902
DOI: 10.1038/sj.mt.6300304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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