Article
Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor.
The Journal of biological chemistry - 16 Nov 2007
Iwamoto Noriko, Sumi Daigo, Ishii Takeshi, Uchida Koji, Cho Arthur K, Froines John R, Kumagai Yoshito
Abstract excerpt
1,2-Naphthoquinone (1,2-NQ), an atmospheric contaminant, causes the contraction of guinea pig trachea through the activation of epidermal growth factor receptor (EGFR) by inhibiting protein-tyrosine phosphatases (PTPs). Phosphorylation of EGFR is negatively regulated by PTPs, but details of the m...
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