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Article

Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation.

Human cell - 1 Jul 2024

Komatsu Hiroaki, Okawa Masayo, Kazuki Yasuhiro, Kazuki Kanako, Hichiwa Genki, Shimoya Kazuto, Sato Shinya, Taniguchi Fuminori, Oshimura Mitsuo, Harada Tasuku

Abstract excerpt

We aimed to elucidate the mechanism underlying carcinogenesis by comparing normal and BRCA1/2-mutated ovarian epithelial cells established via Sendai virus-based immortalization. Ovarian epithelial cells (normal epithelium: Ovn; with germline BRCA1 mutation: OvBRCA1; with germline BRCA2 mutation: OvBRCA2) were infected with Sendai virus vectors carrying three immortalization genes (Bmi-1, hTERT, and SV40T). The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38615309
DOI: 10.1007/s13577-024-01064-z

Genes

BRCA1
BRCA2
MMP1
CCL2
PAPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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