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Article

MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study.

BMC medical genetics - 12 Oct 2015

Hsiao Pi-Jung, Lee Mei-Yueh, Wang Yeng-Tseng, Jiang He-Jiun, Lin Pi-Chen, Yang Yi-Hsin Connie, Kuo Kung-Kai

Abstract excerpt

BACKGROUND: Microsomal triglyceride transfer protein (MTP) works to lipidate and assemble the apoB-containing lipoproteins in liver. It closely links up the hepatic secretion of lipid to regulate serum lipid and atherosclerosis. Cases of MTTP gene mutation is characterized by abetalipoproteinemia and remarkable hepatic steatosis or cirrhosis. Several MTTP polymorphisms have been reported relating to metabolic...

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Identifiers

PMID: 26458397
DOI: 10.1186/s12881-015-0242-6
PMCID: PMC4603340

Genes

MTTP

Variants

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