Article
Plasticity of CD133+ cells: role in pulmonary vascular remodeling.
Cardiovascular research - 1 Dec 2007
Díez Marta, Barberà Joan A, Ferrer Elisabet, Fernández-Lloris Raquel, Pizarro Sandra, Roca Josep, Peinado Victor I
Abstract excerpt
OBJECTIVE: Studies in pulmonary arteries (PA) of patients with chronic obstructive pulmonary disease (COPD) suggest that bone marrow-derived endothelial progenitor cells (CD133(+)) may infiltrate the intima and differentiate into smooth muscle cells (SMC). This study aimed to evaluate the plasticity of CD133(+) cells to differentiate into SMC and endothelial cells (EC) in both cell culture and human isolated PA....
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