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Article

Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 15 Oct 2009

Toshner Mark, Voswinckel Robert, Southwood Mark, Al-Lamki Rafia, Howard Luke S G, Marchesan Denis, Yang Jun, Suntharalingam Jay, Soon Elaine, Exley Andrew, Stewart Susan, Hecker Markus, Zhu Zhenping, Gehling Ursula, Seeger Werner, Pepke-Zaba Joanna, Morrell Nicholas W

Abstract excerpt

RATIONALE: Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of cells contributing to these vascular lesions is uncertain. Endogenous endothelial progenitor cells are potentia...

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Topics

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Endothelial Cells

Share to Hypertension, Pulmonary

Share to Neovascularization, Pathologic

Share to Pulmonary Artery

Share to Stem Cells

Source

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Identifiers

PMID: 19628780
DOI: 10.1164/rccm.200810-1662OC
PMCID: PMC2778151

Genes

PAH
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19628780-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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