Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysfunction of dysferlin-deficient hearts.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2007

Wenzel Katrin, Geier Christian, Qadri Fatimunnisa, Hubner Norbert, Schulz Herbert, Erdmann Bettina, Gross Volkmar, Bauer David, Dechend Ralf, Dietz Rainer, Osterziel Karl Josef, Spuler Simone, Ozcelik Cemil

Abstract excerpt

Mutations in the gene encoding dysferlin cause limb-girdle muscular dystrophy 2B (LGMD2B), a disorder that is believed to spare the heart. We observed dilated cardiomyopathy in two out of seven LGMD2B patients and cardiac abnormalities in three others. Cardiac biopsies showed that dysferlin was c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dysferlin
Share to Echocardiography
Share to Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Function Tests

Share to Isoproterenol

Share to Muscle Proteins

Share to Muscular Dystrophies, Limb-Girdle

Share to Myocardium

Source

Identifiers

PMID: 17828519
DOI: 10.1007/s00109-007-0253-7

Genes

LDB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17828519-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysfunction of dysferlin-deficient hearts.PMID 17828519Read ↗

Dysferlin deficiency blunts β-adrenergic-dependent lusitropic function of mouse heart.Semantic proximity Read ↗

Dysferlin and Animal Models for DysferlinopathySemantic proximity Read ↗

Muscular dystrophy in dysferlin-deficient mouse models.Semantic proximity Read ↗

Dysferlin deficiency confers increased susceptibility to coxsackievirus-induced cardiomyopathy.Semantic proximity Read ↗

Improved immunoblotting methods provide critical insights into phenotypic differences between two murine dysferlinopathy models.Semantic proximity Read ↗

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injurySemantic proximity Read ↗

Dysferlinopathies.Semantic proximity Read ↗

Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency.Semantic proximity Read ↗

Translational research and therapeutic perspectives in dysferlinopathies.Semantic proximity Read ↗

C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered gene expression of muscle enriched genes.Semantic proximity Read ↗

Dysferlin overexpression in skeletal muscle produces a progressive myopathy.Semantic proximity Read ↗

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.