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Article

GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.

The American journal of clinical nutrition - 1 Sept 2007

Cornelis Marilyn C, El-Sohemy Ahmed, Campos Hannia

Abstract excerpt

BACKGROUND: Cruciferous vegetables are a major dietary source of isothiocyanates that may protect against coronary heart disease. Isothiocyanates induce glutathione S-transferases (GSTs), polymorphic genes that code for enzymes that conjugate isothiocyanates, as well as mutagens and reactive oxyg...

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Source

Identifiers

PMID: 17823442
DOI: 10.1093/ajcn/86.3.752

Genes

GSTT1
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17823442-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction.PMID 17823442Read ↗

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Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach.Semantic proximity Read ↗

An updated meta-analysis showed smoking modify the association of GSTM1 null genotype on the risk of coronary heart disease.Semantic proximity Read ↗

Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype.Semantic proximity Read ↗

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Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes.Semantic proximity Read ↗

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