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Article

Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation.

Neurobiology of disease - 1 Dec 2007

Haroon Mohammad Fahad, Fatima Ambrin, Schöler Susanne, Gieseler Anne, Horn Thomas F W, Kirches Elmar, Wolf Gerald, Kreutzmann Peter

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a retinal neurodegenerative disorder caused by mitochondrial DNA point mutations. Complex I of the respiratory chain affected by the mutation results in a decrease in ATP and an increase of reactive oxygen species production. Evaluating the efficacy o...

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Identifiers

PMID: 17822909
DOI: 10.1016/j.nbd.2007.07.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17822909-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation.PMID 17822909Read ↗

Mitophagy activation repairs Leber’s hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survivalSemantic proximity Read ↗

Mesenchymal stem cells (MSCs) in Leber's hereditary optic neuropathy (LHON): a potential therapeutic approach for future.Semantic proximity Read ↗

Mitochondrial replacement in an iPSC model of Leber’s hereditary optic neuropathySemantic proximity Read ↗

Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Emerging model systems and treatment approaches for Leber's hereditary optic neuropathy: Challenges and opportunities.Semantic proximity Read ↗

Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis.Semantic proximity Read ↗

Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy.Semantic proximity Read ↗

Treatment of Leber's hereditary optic neuropathy: theory to practice.Semantic proximity Read ↗

The G11778A LHON mutation does not enhance ethambutol cytotoxicity in a cybrid model.Semantic proximity Read ↗

Mesenchymal stem cell mitochondrial transfer effectively protects Leber's Hereditary Optic Neuropathy (LHON) mutant cells from mitochondrial damage.Semantic proximity Read ↗

Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents.Semantic proximity Read ↗

Functional Characterization of Three Concomitant MtDNA LHON Mutations Shows No Synergistic Effect on Mitochondrial Activity.Semantic proximity Read ↗

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