Article
Rheumatic heart disease: mediation by complex immune events.
Advances in clinical chemistry - 1 Jan 2011
Guilherme L, Köhler K F, Kalil J
Abstract excerpt
Rheumatic fever (RF) is an autoimmune disease caused by the Gram-positive bacteria Streptococcus pyogenes following an untreated throat infection in susceptible children. Rheumatic heart disease (RHD), the most serious complication, occurs in 30-45% of RF patients and leads to chronic valvular lesions. Here, we focus on the genes that confer susceptibility for developing this disease. Molecular mimicry mediates...
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