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Article

Limits on Replenishment of the Resting CD4+ T Cell Reservoir for HIV in Patients on HAART

24 Aug 2007

Abstract excerpt

Whereas cells productively infected with human immunodeficiency virus type 1 (HIV-1) decay rapidly in the setting of highly active antiretroviral therapy (HAART), latently infected resting CD4(+) T cells decay very slowly, persisting for the lifetime of the patient and thus forming a stable reservoir for HIV-1. It has been suggested that the stability of the latent reservoir is due to low-level viral replication...

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PMID: 17784786
DOI: 10.1371/journal.ppat.0030122

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