Article
Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene.
Transfusion - 1 Dec 2007
Seltsam Axel, Wagner Franz F, Grüger Daniela, Gupta Christa D, Bade-Doeding Christina, Blasczyk Rainer
Abstract excerpt
BACKGROUND: Binding of CCAAT-binding factor NF-Y (CBF/NF-Y) to a 43-bp repeat unit in the minisatellite region in the 5' region of the ABO gene (CBF/NF-Y enhancer region) plays an important role in regulating the transcription of ABO genes. The common ABO alleles were found to have CBF/NF-Y enhancer regions with specific numbers of 43-bp minisatellite repeats. MATERIAL AND METHODS: Blood samples from four healthy...
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