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Article

Induction of p53-Regulated Gene Expression in Human Cell Lines Exposed to the Cyanobacterial Toxin Cylindrospermopsin

31 Aug 2007

Abstract excerpt

Cylindrospermopsin (CYN) is a cyanobacterial toxin that induces a range of genotoxic indicators in a variety of models. The possible involvement of the tumor suppressor protein p53 in cylindrospermopsin-induced gene expression was examined in cultured human dermal fibroblasts and the human hepatocellular carcinoma cell line HepG2. After 6 h of exposure to CYN, concentration-dependent increases in mRNA levels were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17763087
DOI: 10.1080/15287390701434877

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