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Article

The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007

Dhasarathy Archana, Kajita Masahiro, Wade Paul A

Abstract excerpt

The estrogen receptor (ER)-alpha (ESR1) is a key regulatory molecule in mammary epithelial cell development. Loss of ER-alpha in breast cancer is correlated with poor prognosis, increased recurrence after treatment, and an elevated incidence of metastasis. A proposed molecular pathway by which ER-alpha acts to constrain invasive growth in breast cancer cells involves direct, ER-alpha-dependent expression of...

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Topics

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Share to Acetylation
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Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mesenchymal Stem Cells

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Share to Snail Family Transcription Factors

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Source

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Identifiers

PMID: 17761946
DOI: 10.1210/me.2007-0293
PMCID: PMC2668600

Genes

ESR1
MTA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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