Article
Immune modulation and microchimerism after unmodified versus leukoreduced allogeneic red blood cell transfusion in cancer patients: results of a randomized study.
Transfusion - 1 Sept 2007
Lapierre Valérie, Aupérin Anne, Robinet Eric, Ferrand Christophe, Oubouzar Nadia, Tramalloni Dominique, Saas Philippe, Debaene Bertrand, Lasser Philippe, Tiberghien Pierre
Abstract excerpt
BACKGROUND: Transfusion of red blood cells (RBCs) has been associated with immunomodulatory effects. Persistence of donor cells in the recipient may be contributive. STUDY DESIGN AND METHODS: A randomized single-center trial was conducted to compare microchimerism and immune responses in 35 patients undergoing cancer surgery and transfused perioperatively with either unmodified RBCs (UN-RBCs, n = 18) or...
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