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Article

Fusion of theEWSR1andATF1genes without expression of theMITF‐Mtranscript in angiomatoid fibrous histiocytoma

9 May 2005

Abstract excerpt

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that usually occurs in children and young adults. Only two cases of AFH with genetic rearrangements have been reported previously; both of these had a FUS-ATF1 fusion gene. We have studied an AFH from a 9-year-old boy whose tumor displayed a t(12;22)(q13;q12) as the sole cytogenetic aberration. FISH,RT-PCR, and sequence analyses revealed an...

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PMID: 15884099
DOI: 10.1002/gcc.20201

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