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Article

ABCB4 mediates diet-induced hypercholesterolemia in laboratory opossums.

Journal of lipid research - 1 Oct 2010

Chan Jeannie, Mahaney Michael C, Kushwaha Rampratap S, VandeBerg Jane F, VandeBerg John L

Abstract excerpt

High-responding opossums are susceptible to developing hypercholesterolemia on a high-cholesterol diet, but low-responding opossums are resistant. The observation of low biliary cholesterol and low biliary phospholipids in high responders suggested that the ABCB4 gene affects response to dietary cholesterol. Two missense mutations (Arg29Gly and Ile235Leu) were found in the ABCB4 gene of high responders. High...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to DNA, Complementary

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Source

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Identifiers

PMID: 20488799
DOI: 10.1194/jlr.M005553
PMCID: PMC2936762

Genes

ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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