Article
Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity.
Neuroscience letters - 20 Sept 2007
Wei Huafeng, Liang Ge, Yang Hui
Abstract excerpt
The commonly used inhaled anesthetic isoflurane has been shown to be both neuroprotective and neurotoxic in various cell cultures and animal models. We hypothesize that, like cerebral ischemia, isoflurane is inherently neurotoxic. Limited exposure of isoflurane provides neuroprotection via induction of endogenous neuroprotective mechanisms (preconditioning), while prolonged exposure of isoflurane induces...
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