Article
Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells.
FEBS letters - 18 Sept 2007
Andrade Arturo, de León Mario Bermúdez, Hernández-Hernández Oscar, Cisneros Bulmaro, Felix Ricardo
Abstract excerpt
We previously reported that expression of myotonic dystrophy (DM1) expanded CUG repeats impedes NGF-induced differentiation in a PC12 clone (CTG90 cells). Here, we present evidence for changes in the fractional contribution of distinct voltage-gated Ca(2+) channels, key elements in neurotrophin-promoted differentiation, to the total Ca(2+) current in the CTG90 cells. Patch-clamp recordings showed that the...
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