Article
Frequency and clinical features of the JAK2 V617F mutation in pediatric patients with sporadic essential thrombocythemia.
Pediatric blood & cancer - 1 Dec 2008
Nakatani Takuya, Imamura Toshihiko, Ishida Hiroyuki, Wakaizumi Katsuji, Yamamoto Tohru, Otabe Osamu, Ishigami Tsuyoshi, Adachi Souichi, Morimoto Akira
Abstract excerpt
BACKGROUND: Pediatric essential thrombocythemia (ET) is a rare and heterogenous disease entity. While several recent studies have focused on the role of the JAK2 V617F mutation in pediatric ET, the frequency of pediatric ET cases with this mutation and the associated clinical features remain unclear. PROCEDURE: We examined six childhood cases who had been diagnosed with ET according to WHO criteria (onset age:...
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