Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650).

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2007

Wang Jian, Cao Henian, Ban Matthew R, Kennedy Brooke A, Zhu Siqi, Anand Sonia, Yusuf Salim, Pollex Rebecca L, Hegele Robert A

Abstract excerpt

OBJECTIVE: The genetic determinants of severe hypertriglyceridemia (HTG; MIM 144650) in adults are poorly defined. We therefore resequenced 3 candidate genes, namely LPL, APOC2, and APOA5, to search for accumulation of missense mutations in patients with severe HTG compared with normolipidemic subjects. METHODS AND RESULTS: We resequenced >2 million base pairs of genomic DNA from 110 nondiabetic patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-V
Share to Apolipoprotein C-II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins A

Share to Case-Control Studies

Share to Hypolipidemic Agents

Share to Lipoprotein Lipase

Share to Mutation, Missense

Share to White People

Source

Identifiers

PMID: 17717288
DOI: 10.1161/ATVBAHA.107.150680

Genes

APOA5
APOC2
LPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650).PMID 17717288Read ↗

Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia.Semantic proximity Read ↗

Genetic Determinants of Severe Hypertriglyceridemia: Rare Variants in LPL, APOC2, APOA5, GPIHBP1, LMF1, APOE and Polygenic Risk.Semantic proximity Read ↗

Molecular and functional characterization of familial chylomicronemia syndrome.Semantic proximity Read ↗

Genetic Variants in Severe Hypertriglyceridemia Among Taiwanese Participants - Insights From Genome-Wide Association and Whole-Exome Sequencing Analyses.Semantic proximity Read ↗

The polygenic nature of mild-to-moderate hypertriglyceridemia.Semantic proximity Read ↗

Partial LPL deletions: rare copy-number variants contributing towards severe hypertriglyceridemiaSemantic proximity Read ↗

Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.Semantic proximity Read ↗

Rare and common variants in LPL and APOA5 in Thai subjects with severe hypertriglyceridemia: A resequencing approach.Semantic proximity Read ↗

Pathogenicity assessment of genetic variants identified in patients with severe hypertriglyceridemia: Novel cases of familial chylomicronemia syndrome from the Dyslipidemia Registry of the Spanish Atherosclerosis SocietySemantic proximity Read ↗

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.Semantic proximity Read ↗

Genetic bases of hypertriglyceridemic phenotypes.Semantic proximity Read ↗

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.