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Production of Pseudoinfectious Yellow Fever Virus with a Two-Component Genome

23 Aug 2007

Abstract excerpt

Application of genetically modified, deficient-in-replication flaviviruses that are incapable of developing productive, spreading infection is a promising means of designing safe and effective vaccines. Here we describe a two-component genome yellow fever virus (YFV) replication system in which each of the genomes encodes complete sets of nonstructural proteins that form the replication complex but expresses...

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PMID: 17715227
DOI: 10.1128/jvi.01112-07

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