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Article

Overloading of stable and exclusion of unstable human superoxide dismutase-1 variants in mitochondria of murine amyotrophic lateral sclerosis models.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Apr 2006

Bergemalm Daniel, Jonsson P Andreas, Graffmo Karin S, Andersen Peter M, Brännström Thomas, Rehnmark Anna, Marklund Stefan L

Abstract excerpt

Mutants of human superoxide dismutase-1 (hSOD1) cause amyotrophic lateral sclerosis (ALS), and mitochondria are thought to be primary targets of the cytotoxic action. The high expression rates of hSOD1s in transgenic ALS models give high levels of the stable mutants G93A and D90A as well as the w...

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Identifiers

PMID: 16624935
DOI: 10.1523/JNEUROSCI.5461-05.2006
PMCID: PMC6673995

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16624935-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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