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Article

Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.

Cephalalgia : an international journal of headache - 1 Aug 2009

Rubino E, Ferrero M, Rainero I, Binello E, Vaula G, Pinessi L

Abstract excerpt

There are conflicting data concerning the association between migraine and C677T polymorphism of the MTHFR gene. The C677T polymorphism reduces enzymatic capability by 50% and causes hyperhomocysteinaemia. We performed a meta-analysis of all published studies investigating the association between...

Read the complete abstract on PubMed

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Share to MTHFR gene
Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Migraine Disorders

Share to Polymorphism, Single Nucleotide

Share to Risk Assessment

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Source

Identifiers

PMID: 17714520
DOI: 10.1111/j.1468-2982.2007.01400.x

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17714520-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis.PMID 17714520Read ↗

MTHFR C677T polymorphism and migraine risk: a meta-analysis.Semantic proximity Read ↗

Relation between Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Migraine SusceptibilitySemantic proximity Read ↗

MTHFR T677 Homozygosis Influences the Presence of Aura in MigraineursSemantic proximity Read ↗

Migraine and MTHFR C677T genotype in a population-based sample.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.Semantic proximity Read ↗

MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.Semantic proximity Read ↗

Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk.Semantic proximity Read ↗

Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura - a preliminary report.Semantic proximity Read ↗

Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine.Semantic proximity Read ↗

The C677T polymorphism in MTHFR is not associated with migraine in Portugal.Semantic proximity Read ↗

Targeting MTHFR for the treatment of migrainesSemantic proximity Read ↗

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