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Article

Multiple novel alterations in<i>Kit</i>tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder

1 Jan 2007

Abstract excerpt

OBJECTIVE: Sequencing efforts to discover mutations in the tyrosine kinase Kit related to systemic mast cell disorders have so far been focused mainly on only a few of the 21 exons of the encoding gene c-kit, thus considerably limiting the possibility to quantitatively reveal pathogenetic relationships. The purpose of this study was to analyze and compare the total sequence of Kit tyrosine kinase at the level of...

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PMID: 17710669
DOI: 10.1080/00365520701245744

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