Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics.

Immunology - 1 Nov 2012

Haenisch Britta, Nöthen Markus M, Molderings Gerhard J

Abstract excerpt

Despite increasing understanding of its pathophysiology, the aetiology of systemic mast cell activation disease (MCAD) remains largely unknown. Research has shown that somatic mutations in kinases are necessary for the establishment of a clonal mast cell population, in particular mutations in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Bullous Skin Diseases
Share to Eosinophilic Disorders and Syndromes
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast cells and histamine

Share to Mastocytosis, Systemic

Share to Mutation

Share to Polymorphism, Genetic

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 22957768
DOI: 10.1111/j.1365-2567.2012.03627.x
PMCID: PMC3482677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22957768-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics.PMID 22957768Read ↗

The genetic basis of mast cell activation disease - looking through a glass darkly.Semantic proximity Read ↗

Familial Occurrence of Systemic Mast Cell Activation DiseaseSemantic proximity Read ↗

How we diagnose and treat systemic mastocytosis in adults.Semantic proximity Read ↗

Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects.Semantic proximity Read ↗

Mutational profiling in the peripheral blood leukocytes of patients with systemic mast cell activation syndrome using next-generation sequencing.Semantic proximity Read ↗

Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression.Semantic proximity Read ↗

Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations.Semantic proximity Read ↗

Molecular defects in mastocytosis: KIT and beyond KIT.Semantic proximity Read ↗

Current state of biology and diagnosis of clonal mast cell diseases in adults.Semantic proximity Read ↗

Mastocytosis and Mast Cell Activation Disorders: Clearing the AirSemantic proximity Read ↗

Mastocytosis.Semantic proximity Read ↗

Detection of KIT Mutations in Systemic Mastocytosis: How, When, and Why.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.