Article
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.
American journal of human genetics - 1 Sept 2007
Otonkoski Timo, Jiao Hong, Kaminen-Ahola Nina, Tapia-Paez Isabel, Ullah Mohammed S, Parton Laura E, Schuit Frans, Quintens Roel, Sipilä Ilkka, Mayatepek Ertan, Meissner Thomas, Halestrap Andrew P, Rutter Guy A, Kere Juha
Abstract excerpt
Exercise-induced hyperinsulinism (EIHI) is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. We aimed to identify the molecular basis of this novel disorder of beta -cell regulation. EIHI mapped to chromoso...
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