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Article

Characterization of the human SLC30A8 promoter and intronic enhancer

28 Jul 2011

Abstract excerpt

Genome-wide association studies have shown that a polymorphic variant in SLC30A8, which encodes zinc transporter-8, is associated with altered susceptibility to type 2 diabetes (T2D). This association is consistent with the observation that glucose-stimulated insulin secretion is decreased in islets isolated from Slc30a8 knockout mice. In this study, immunohistochemical staining was first used to show that...

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PMID: 21798992
DOI: 10.1530/jme-11-0055

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