Article
When less is more: the forbidden fruits of gene repression in the adult β-cell.
Diabetes, obesity & metabolism - 1 Jun 2013
Pullen T J, Rutter G A
Abstract excerpt
Outside of the biological arena the term 'repression' often has a negative connotation. However, in the pancreatic β-cell a small group of genes, which are abundantly expressed in most if not all other mammalian tissues, are highly selectively repressed, with likely functional consequences. The two 'founder' members of this group, lactate dehydrogenase A (Ldha) and monocarboxylate transporter-1 (MCT-1/Slc16a1),...
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