Article
Prolyl 4-hydroxylase-1 mediates O2 signaling during development of Dictyostelium.
Development (Cambridge, England) - 1 Sept 2007
West Christopher M, van der Wel Hanke, Wang Zhuo A
Abstract excerpt
Development in multicellular organisms is subject to both environmental and internal signals. In Dictyostelium, starvation induces amoebae to form migratory slugs that translocate from subterranean areas to exposed sites, where they culminate to form sessile fruiting bodies. Culmination, thought to be regulated by anterior tip cells, is selectively suppressed by mild hypoxia by a mechanism that can be partially...
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