Article
Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans.
Diabetes - 1 Nov 2007
Puppala Sobha, Arya Rector, Thameem Farook, Arar Nedal H, Bhandari Kusum, Lehman Donna M, Schneider Jennifer, Fowler Sharon, Farook Vidya S, Diego Vincent P, Almasy Laura, Blangero John, Stern Michael P, Duggirala Ravindranath, Abboud Hanna E
Abstract excerpt
OBJECTIVE: Glomerular filtration rate (GFR) is used to assess the progression of renal disease. We performed linkage analysis to localize genes that influence GFR using estimated GFR data from the San Antonio Family Diabetes/Gallbladder Study. We also examined the effect of genotype by diabetes interaction (G x DM) on the detection of linkage to address whether genetic effects on GFR differ in diabetic and...
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