Article
[Gefitinib and epidermal growth factor receptor gene mutation].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Aug 2007
Fukui Takayuki, Mitsudomi Tetsuya
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene mutations are frequent in lung cancer of Asian ethnicity, female gender, non-smokers,and of adenocarcinoma histology. About 80% of the patients with EGFR mutations respond to EGFR tyrosine kinase inhibitor (TKI) including gefitinib and erlotinib, while only 10% of those without EGFR mutations do so. Therefore, EGFR mutation is being recognized as one of the most...
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