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Article

Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment.

The journal of gene medicine - 1 Oct 2007

Luo Chenhong, Mori Isamu, Goshima Fumi, Ushijima Yoko, Nawa Akihiro, Kimura Hiroshi, Nishiyama Yukihiro

Abstract excerpt

Cells expressing herpes simplex virus (HSV) thymidine kinase (tk) are killed by ganciclovir (GCV). Adjacent cells without HSV-tk also die, a phenomenon known as the 'bystander effect'. However, there is no evidence that replication-competent HSV induces a bystander effect in the presence of GCV. Therefore, we investigated the bystander effect in HEp-2 cells infected with replication-competent, oncolytic HSV-1...

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Identifiers

PMID: 17685493
DOI: 10.1002/jgm.1085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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